Using Teststand 2016 32 bit with (Labview 2012 32 bit) & Windows 10 and a new PC with 8GB memory, I found that it is very slow to open (4 minutes) and strangely slow to close (1 minute); its so slow that you start thinking that it has crashed.
When running sequences it is ok, and closing the sequence is ok.
I read somewhere that it could be the search directories structure that could cause it to be slow and am unsure which search directories are really needed, and which are not, also some of the files are in absolute paths; however why would Windows be slow to close TestStand?